

Meta-regression showed that the association was influenced by age (p = 0.008), but not by diabetes (p = 0.423), and cardiovascular disease (p = 0.086).Ĭonclusion: Physicians should be more aware and take extra precautions with diabetes patients who use insulin therapy. Statistical analysis was performed using the software programs Comprehensive Meta-Analysis version 3.3.070 (Biostat, Englewood, NJ) and Review Manager (RevMan) version 5.3.5 (The Nordic Cochrane Centre, The Cochrane Collaboration, 2014, Copenhagen, Denmark). Results: Our pooled analysis showed that insulin use was associated with poor composite development of COVID-19, and its subgroup which comprised of risk of COVID-19, severe COVID-19, and mortality. Statistical analysis was done using Review Manager 5.4 and Comprehensive Meta-Analysis version 3 software.

All articles published on COVID-19 and insulin were retrieved. Methods: We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until December 12th, 2020.

Our study aims to evaluate the possible association between insulin and the poor composite development of COVID-19. Insulin therapy and outcome from coronavirus disease 2019 (COVID-19): A Systematic Review, Meta-Analysis, and Meta-Regression (E-pub Abstract Ahead of Print)įaculty of Medicine, Pelita Harapan University, Boulevard Jendral Sudirman street, Karawaci, Tangerang, Indonesia Nata Pratama Hardjo Lugito ,ĭepartment of Internal Medicine, Faculty of Medicine, Pelita Harapan University, Boulevard Jendral Sudirman street, Karawaci, Tangerang, Indonesia Theo Audi Yanto ,ĭepartment of Internal Medicine, Faculty of Medicine, Pelita Harapan University, Boulevard Jendral Sudirman street, Karawaci, Tangerang, Indonesia Jeremia Immanuel Siregar ,ĭepartment of Internal Medicine, Faculty of Medicine, Pelita Harapan University, Boulevard Jendral Sudirman street, Karawaci, Tangerang, Indonesia Andree Kurniawan* Department of Internal Medicine, Faculty of Medicine, Pelita Harapan University, Boulevard Jendral Sudirman street, Karawaci, Tangerang, Indonesiaīackground: Currently, the relationship between insulin therapy and COVID-19 outcome is not yet established. Review Manager software (RevMan version 5.4.1) Also called the Cochrane’s Review Manager, it is a freely available software, initially built to ease the planning of protocols, the writing of.
